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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are typically characterized by a focus on practical aspects of the research design, like recruitment and consent as well as adherence to the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from different geographical regions. This kind of heterogeneity is essential for practical trials to be valid and reduces bias in the results. Too much heterogeneity, however, 무료 프라그마틱 슬롯 조작 (new content from Theflatearth) can cause problems with the design of the trial.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are typically commissioned by policymakers and practitioners in order to guide their decisions. They can also be used to determine the causal relationship between an intervention and its results. They should not, however, be used to replace the need for explanation studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study, including recruitment, design, implementation of the intervention, and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.