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Pragmatic trials are studies designed to provide information for real-world clinical practice. They are typically described as focusing on practical aspects of designing a study that include recruitment and consent, adherence and the use routinely available equipment.

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RTP

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from different geographical regions. This type of heterogeneity which is essential for pragmatic trials to be valid and reduce bias in results is also essential. However too much heterogeneity could cause issues with the design of the trial.

Pragmatic Play is a major player on the live casino market, provides various classic table games like Blackjack and Roulette. The live studios of the company in Romania and Malta offer an authentic gaming experience for its customers and offer an extensive selection of virtual betting options. The company also has several games which make online gambling enjoyable and engaging. Some of these shows are hosted live and some feature famous personalities in the industry.

Mobile compatibility

Pragmatic Play, a new player in the field of online casinos, has gained a reputation for its mobile-friendly slot machines. Their games are optimized for mobile devices, and run on HTML5 technology. They're also endorsed by reputable gaming authorities to ensure fairness and transparency. This is a great indication for players as it implies that the games are tested and verified to ensure that the results of every round are random and fair.

Pragmatic Play offers not only mobile-friendly slot machines, but also live casino and table games. The company is licensed and regulated by a variety of authorities which include the Malta Gaming Authority and UK Gambling Commission. The company's games are secured by top-of-the-line encryption and its security team is available to assist players in any situation.

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Legality

Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. Its software is designed to work on mobile devices and is compatible with various languages. It has earned itself the status of one of the top casino gaming platforms despite its relative infancy. The most recent releases include Wolves 5 reel video slot with a healthful RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by practitioners and policy makers to aid in their decision-making. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. They should not, however be used to replace explanatory studies.

The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials that inform the practice and policy decisions. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a practical trial, including the recruitment process, the design and implementation of the intervention, and the follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more acquaint to the issue of pragmatics. It is important to note that the majority of studies were conducted in primary-care settings.